Note: This game is also titled Biohazard 3: Last Escape.
Successfully complete the game once on any difficulty setting and wait for the credits to end, then save the "Next Game" file to unlock "The Mercenaries" mini-game. Start a new game, choose that saved game, then select "The Mercenaries" mode. This mode involves controlling Carlos, Mikhal, or Nikoli from the train to the starting room with a two minute timer. Killing the various opponents and rescuing civilians during the journey will add extra money and more time to the clock. A rank and money will be awarded after the game is completed. The money can be used to purchase better weapons and infinite ammunition.
Successfully complete the game once and wait for the credits to end, then save the "Next Game" file to receive the key to the Boutique on the first street at the start of the game. Use the key to enter and change into an alternate costume.
Successfully complete the game on the easy difficulty setting with any rank better than an F to unlock Jill's costume from the original Resident Evil and Regina's costume from Dino Crisis. Successfully complete the game on the hard difficulty setting with a rank of D to unlock two costumes, C for three, B for four, and A for all five costumes. The three additional costumes are a police miniskirt, disco, and biker outfits.
Successfully complete the game on any difficulty setting.
You can only create enhanced ammo while playing on the hard difficulty setting. When creating ammo with the reloading tool, save enough gunpowder to mix up the same type of ammo eight times. On the eighth time, the game will prompt "Do you want to create the enhanced ammo?". Select "Yes". This ammo is more powerful, may have slightly different effects, and once loaded into a weapon will change it into an "enhanced weapon". You can only create two types of enhanced ammo: 9mm handgun bullets and shot gun shells. The only different effects the new bullets have is that they are far more powerful.
When you first get to the trolley, Carlos will give you a "fanny" pack. After you finish the game, you will keep those additional two slots in the game.
Successfully complete the game on the hard difficulty setting to unlock an Epilogue. Epilogues are a short diary description of each character in the entire Resident Evil series which describes what happened with that specific person after their adventure. Successfully complete the game on the hard difficulty setting eight times to unlock all Epilogues. All eight Epilogues read as followed:
- Jill Valentine
After escaping the city, Jill set out to join Chris Redfield. However, all she found was an empty hideout of Chris's. On the floor was Chris's knife. Jill left without hesitation because she firmly believes that Chris is still alive. She will search for him until she finds him. Then they can go and put an end to Umbrella...
- Chris Redfield
"Please forgive me Claire." Chris Redfield has just finished this letter with his signature phrase. As he removes his sunglasses, a lady walks by him with light steps. "She looks about the same age as Claire," he thinks. A short time later, Chris discovered that his sister was looking for him, but was caught...
- Barry Burton
Barry Burton looks at his young daughters and says, "I'm sorry but my comrades are waiting for me." He knows that he must repay his teammates for forgiving his betrayal. Even if that means leaving his family for now. His wife tries to hide her fear, so she smiles and says, "Don't worry. We'll be OK..."
- Leon Kennedy
Leon Scott Kennedy is confronted by a man who claims to be a U.S. government agent. Leon says, "Leave Sherry alone. She is innocent." "She knows too much," the man replies. He looks at Leon and says, "But you have value. This is a good deal. Make your choice." Without regret or hesitation, Leon closes his eyes and then sharply responds...
- Claire Redfield
"Leave us alone." Claire Redfield couldn't believe Leon's words. Leon continued, "You're looking for your brother, right? Just go!" Claire knew that Leon and Sherry needed immediate medical attention, but she could not waste anymore time. "I... I'll be back. I promise!" She said as she disappeared into the wilderness alone...
- Sherry Birkin
"Do you have any relatives?" When the army officer asked her, Sherry Birkin did not respond for she has no immediate relatives. Her father and mother died because of the G-virus. And so, this little girl holds herself with her arms and bites her lip tight. She thinks, "I'm sure she will come back. She won't forget about me..."
- Ada Wong
A woman looks at herself in the mirror. She used to be called Ada Wong... But this morning she will say good-bye to the name. "I'm not Ada Wong anymore..." She feels her ab and thinks, "This is Ada's scar, not mine." And as she says good-bye to Ada Wong, she can't stop her tears. However, there isn't much time left before her next mission...
- Hunk, the 4th Survivor
"Once again, only you survived, Mr. Death," the chopper pilot speaks with a cold bitterness. "Always, only you, survive, Mr. Death," the pilot continues. But Hunk does not respond to the pilot. He doesn't care. "The Death cannot die...," the survivor thinks to himself with a warm smile...
- Chris Redfield
Collect all thirty notes and books in the game to replace the first book in your file with Jill's Diary. Jill's Diary reads as followed:
- August 7th
Two weeks have passed since that day. My wounds have been healed, but I just can't forget it. For most people, it's history now. But for me, whenever I close my eyes, it all comes back clearly. Zombies eating people's flesh and the screams of my teammates dying. No, the wounds in my heart are not healed yet...
- August 13th
Chris has been causing a lot of trouble recently. What's with him? He seldom talks to the other police members and is constantly irritated. The other day, he punched Elran of the Boy's Crime department just for accidentally splashing Chris's face with coffee. I immediately stopped Chris, but when he saw me he just gave me a wink and walked away. I wonder what happened to him...
- August 15th
Midnight. Chris, who has been on a leave of absence for a "vacation," called me so I visited his apartment. As soon as I walked into his room, he showed me a couple of pieces of paper. They were part of a virus research report entitled as simply as "G". Then Chris told me that, "The nightmare still continues." He went on to say that, "It's not over yet." Ever since that day, he has been fighting all by himself without rest, without even telling me...
- August 24th
Chris left the town today to go to Europe. Barry told me that he would send his family to Canada and then he would follow Chris. I decided to remain in Raccoon City for a while because I know that the research facility in this city will be very important to this entire case. In a month or so, I'll be joining with them somewhere in Europe. That's when my real battle begins...
- August 13th