Successfully complete one of the following tasks to get a trophy:

    The Inoculator (Bronze): Survive for 5 minutes or more in Arcade Mode.
    Clean-a-rama (Bronze): Get a combo-pop of 100 or more germs with one shot.
    The Marksman (Bronze): Finish any Puzzle level with a single shot.
    Germ-a-thon (Silver): Complete 20 different levels in a single run in Puzzle Mode.
    Micro-Cleaner (Silver): Complete all Story Mode levels.
    Sound Logic (Silver): Complete all Puzzle Mode levels.
    Photo Finish (Silver): Win the 15th round in a Duel match against "The Germinator".
    Oozie (Bronze): Fire 50 germs in a single Story, Duel, or Arcade level.
    Feverish Cleaning (Bronze): Complete a Story Mode level in under 30 seconds.
    The Germinator (Gold): Collect all stars in Puzzle and Story Mode.

Additionally, there are two secret trophies:

    Mother of all Pops (Bronze): Pop a germ of size 25x or greater.
    All Gummed Up (Bronze): Lose any Story Mode level within 5 seconds.
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