Successfully complete one of the following tasks to get a trophy:
- The Inoculator (Bronze): Survive for 5 minutes or more in Arcade Mode.
- Clean-a-rama (Bronze): Get a combo-pop of 100 or more germs with one shot.
- The Marksman (Bronze): Finish any Puzzle level with a single shot.
- Germ-a-thon (Silver): Complete 20 different levels in a single run in Puzzle Mode.
- Micro-Cleaner (Silver): Complete all Story Mode levels.
- Sound Logic (Silver): Complete all Puzzle Mode levels.
- Photo Finish (Silver): Win the 15th round in a Duel match against "The Germinator".
- Oozie (Bronze): Fire 50 germs in a single Story, Duel, or Arcade level.
- Feverish Cleaning (Bronze): Complete a Story Mode level in under 30 seconds.
- The Germinator (Gold): Collect all stars in Puzzle and Story Mode.
Additionally, there are two secret trophies:
- Mother of all Pops (Bronze): Pop a germ of size 25x or greater.
- All Gummed Up (Bronze): Lose any Story Mode level within 5 seconds.