The ending is always different depending how much Quarma you have. Save as many people as possible, because you may not be able to complete the game at the end. if your Quarma level is low, you will see a FMV sequence that shows the Fuzzles killing you. The level is after you get Lulu rich, and you enter the ship.
Hold L to chant and create a Possession Orb made from Spooce. The longer you Chant, the larger the Orb (and farther it can travel). Once formed, you can move the Orb around the level. However, it will sink if you try to bring it across water. If you do not use the Orb within a certain amount of time it will disappear.
On the later levels when using Abe or Munch, have the character you are not controlling stand next to a health vending machine. When Abe (for example) gets hit, switch back to Munch, use the machine, then quickly tap Character Change before the little guy drinks. You will find the health power-up will go to the character who is nowhere near the vending machine (in this case Abe).
As soon as you jump out of the water, immediately press A when you see Munch's headport.
A quick way to get across water is take control of Abe and jump repeatedly. You may lose life. Quickly press A to avoid going in the water.
When being chased as Abe, repeatedly press A.