Successfully complete one of the following tasks to get a trophy:
- Star Struck (Bronze): Collect all 3 Star Germs in 5 consecutive Campaign levels during one play session.
- Germ-A-Go-Round (Bronze): In a single shot, bounce a germ off of Deflectors and walls at least 12 times.
- Cross Fire (Bronze): Activate both a Yellow and Orange Power Germ in a single shot.
- Breaking The Ice (Bronze): Break the ice off of at least 10 germs in one level with 10 unique shots.
- Into The Spike Again, Dear Germs (Bronze): In one level, have 10 germs you didn't shoot pop on Spikes.
- Beam Me Up, Germy! (Bronze): Use a Warp Gate 5 times in a single Puzzle level.
- Highly Contagious (Bronze): Get 20 or more Contagious Gummies on-screen at once in Arcade Mode.
- We Eat Contagions For Breakfast (Bronze): Have a Blue Power Germ consume at least 3 Contagious Gummies when activated.
- Ms. Cupid (Bronze): Activate a Pink Power Germ 12 times.
- Campaign Queen (Silver): Complete all 75 Levels of Campaign Mode, getting at least one star on each level.
- Puzzle Queen (Silver): Complete All 75 levels of Puzzle Mode, getting at least one star on each level.
- Completionist (Gold): Get all 450 stars in Campaign and Puzzle mode.
Additionally, there is one secret trophy:
- Blinky, Pinky, Inky, and Sue (Silver): Absorb a Red, Pink, Yellow, and Orange germ with a Blue Power Germ.