Note: This game is also titled Biohazard 4.
Successfully complete the game to unlock the Separate Ways and Mercenaries mini-games; the Professional difficulty setting; Leon's Raccoon City Police Department costume, Ashley's pop star costume, and Ada's black costume; the Mathilda handgun and Infinite Rocket Launcher for purchase (for 1 million Pesetas), and the Tactical Vest (for 60,000 Pesetas); and an alternate title screen. After completing the game the first time, start a new game, then press Start and select "Load Game". Choose the file that is marked "Clear". Once you choose that file, you will be taken to a menu where you can buy the Matilda Handgun or the Infinite Rocket Launcher. Once you start the game, all of your items from your previous game will be in your item box.
Successfully complete the Separate Ways mini-game to unlock Ashley's knight costume and Leon's gangster costume. Ashley's suit of armor is bullet and damage proof. She cannot get hurt by anything and it is so heavy she cannot be carried away. You do not have to worry about giving her First Aid Sprays, Herbs, or shooting Ganados trying to pick her up.
Successfully complete the game in Professional mode. The merchant will give you a PRL 412 laser cannon when you start Round 2 of Professional mode.
Successfully complete the Separate Ways mini-game to unlock the Chicago Typewriter (Tommy gun with infinite ammunition) for purchase (for 1 million Pesetas).
Get a five star rank with all mercenaries in the Mercenaries mini-game to unlock the HandCannon weapon. To get unlimited ammunition for it, fully upgrade all of the HandCannon's options. Alternately, successfully complete the game two times. The HandCannon will be available as soon as you start the game again for 0 Pesetas. It is a very powerful magnum, and will have unlimited ammunition. When you go to upgrade it in the merchant window, in the "HandCannon" update screen there is an option labeled "Exclusive". When chosen, the gun is upgraded with power identical to the Chicago Typewriter.
Destroy at least ten of the fifteen blue medallions (there are seven in the farm and eight in the cemetery) to get a free Punisher from the Merchant two guns before you can buy it. This pistol hits two targets when you get it and five when you get exclusive.
Get a four star rank in the following areas to unlock the corresponding character in the Mercenaries mini-game:
- Ada Wong: Pueblo
- Albert Wesker: Waterworld
- Hunk: Island Commando Base
- Jack Krauser: Castle
- Albert Wesker: Waterworld
The main monsters to look out for are the two chainsaw ladies on stage 1. Once you kill them, they keep coming back. On stage 2 and 3 be careful of the guys with the chain guns. On stage 4, there is a super chainsaw man. He is bigger than the normal one and has a twin bladed saw. He is almost impossible to stop. He does not climb ladders. He jumps to where he needs to be. He will run at you, swinging the saw. Do not run past him. Turn and jump down if you can, or climb something quickly. If you really want to get past him, try using Jack Krauser's transformation, and aim right at him. If you miss, you are dead. Additionally, Krauser's transformation will kill anyone in one hit as long as you are close enough. Also Flash Bang, Kick are very good for crowds with Krauser. These two things will make Krauser the easiest to get five stars with.
Go to the top of the barn (located next to the house where you found the shotgun in the main game). There is also a timer under the ladder, and a chest above, and up the ladder. Go up there and wait for the Los Illuminados to come to you. When they are mostly packed in, shoot the barrel inside and jump down quickly. Get what they dropped. Get back up the ladder and repeat. Note: Do not throw a grenade while there is a flame barrel down there; it will not do twice the damage. Also, be careful of the Chainsaw Hags that appear. They will cut off your head if you get too close. It is best if you are Hunk or Krauser to use the neck break; and the transformation of Krauser's arm, which kills them in one hit. With Ada or Wesker, use their sniper rifles until they are both gone, then jump down, With Leon try grenades, but it is very difficult.
The best way to complete the game in Professional mode is to first complete the Separate Ways mini-game. You will unlock Ashley's knight costume and Leon's gangster costume. Selecting Ashley's knight costume makes Professional mode a lot easier. Ashley cannot be injured or carried away. Use her for bait when needed. At least half the enemies will go directly for her, giving you time to kill them and keep your distance from a crowd. This also works well on El Gigante.
At the title screen, press the Right Analog-stick to move the background. Press R1 to zoom in or L1 to zoom out.
Remain idle at the title screen. Eventually two trailers will begin playing and begin to cycle.
When Leon is being choked by Chief Mendez, he will be told that he has the same blood. Leave the room, then return. You will be choked again by Chief Mendez, only this time Ada will come to the rescue.
Wait until you are low on ammunition before upgrading a gun. The replacement gun will always have a full clip, giving you extra bullets that otherwise may be difficult to find.
Once you gain access to the tunnel with the merchant beyond Pueblo, return to the farm area and wait for the chickens there to lay eggs. Exit and re-enter to begin the same process over again. After you fill your inventory, you can return to the nearby merchant to sell your eggs. White chicken eggs sell for 300 Pesetas, brown eggs for 600 Pesetas, and golden eggs for 3,000 Pesetas.
If you mix a Green, Red, and Yellow Herb, you can sell it for a lot of money, or use it to restore health and increase the maximum health. Use it when you are low on health so that you do not waste the health recovery from it.
Tap X(2) when the "Open" action appears to kick open or down some doors instead of nudging them by hand. This will give you an advantage, as any enemies behind the door will be sent flying back.
There are many locks on doors. Instead of shooting the locks and wasting ammunition, pull out your knife and cut it off. The same can be done for boxes.
Use the D-pad and Analog-stick together to aim faster than normal.
To avoid getting hurt by traps such as explosives and bear traps, use your laser sight and shoot at the explosive or the middle of the trap.
To find items, smash all of the crates with either your knife or a gun.
When running around different areas of the village, you will see crows. Pick them off from a distance as to not scare the others away. They usually drop Pesetas. Note: If you scare some away, just re-enter the area to reset their position.
If you plan to sell two or more herbs or other items that can be combined, combine them first and do not sell them separately. This will result in a small boost in the total selling price when compared to what it would have been if you sold them separately.
Close to the start of the game there is a pendant with a value that will decrease by 9,000 Pesetas, if dropped in water. To keep it as the Pearl Pendant instead of the Brass Pocketwatch, shoot the block that is holding the well open, then shoot the pendant down to pick it up off the top of the well cover. It will sell for 10,000 Pesetas.
When around the village stage, some trees will have bird nests. Shoot them down to get valuable jewels to sell to the merchant.
Kill Salazar's "right hand" that you need to use the liquid nitrogen tanks on to receive the "Crown Jewels". which fit into the "Crown" treasure item. This is difficult; try using the Chicago Typewriter.
Note: This trick involves the infinite rocket launcher (successfully complete the game; costs 1 million Pesetas). When you fight Saddler and Ada throws you the rocket launcher (special), take it, but do not use it. When you can get a clear shot to his main eye, use the regular unlimited launcher. Saddler will be killed and the rocket launcher (special) will be yours to keep. When you start a new game, you can sell it to the merchant.
An intermission sequence will start when you are escorting Ashley across a bridge. A large crowd shows up and you will run into a farmhouse. After the sequence ends and you are inside the house with Lou, push the bookcases in front of the windows and go to the bottom of the staircase. Using the shotgun is recommended, but the pistol works fine. Once they are able to gain entrance to the house, aim high and fire until they are all knocked down. Then, reload and repeat until Lou tells you to head up stairs. When you do this, go over to the windows and knock down the ladders. After that is done, go to the edge of the stairs and kill everyone that is coming up Grenades work the best for this. After they are taken care of, rush back to the windows and knock down the ladders once again. Repeat this until the sequence plays when they retreat.
Once in the farmhouse, collect all the items while pushing the shelves against the windows. Stand in the corner by the stairs with Luis and fire until he tells you to go upstairs. Once up, stand in northwest corner (when facing down the stairs), and concentrate on firing in the direction of the stairs and pushing down the two ladders in that corner so that you do not become surrounded.
Because the raid continues until you kill a certain number, block two windows and shoot out the third until the enemies break in. Then, block the third window and deal with the other two. This allows you to get several kills in before it starts getting hectic.
Soon after the farmhouse, look around to collect some ammunition and buy more items. After that, go to an opening where you see a lever. Go up to it and switch it to the right to fight El Gigante (recommended) or switch it to the left to face more chainsaw wielding villagers (extremely difficult). If you select to fight El Gigante, aim at the rock at the top ledge until he is underneath it and fire. Use the same tactic on the one you dealt with earlier.
After you kill the hatchet guy as soon as you start the game, go upstairs to the window. Do not jump out. Instead, take out your pistol and shoot the glass out. Then, carefully aim for the villagers' heads that are awaiting outside. There are three of them. If you kill all three, you can jump out and avoid any damage.
Shoot out the legs of everyone, then unload on their heads while they are lying on their faces.
Throw a flash grenade in the middle of a group of birds. All of them will die instantly, leaving lots of gold. This also works with the Granadas when their heads are transformed.
If you see a snake after smashing boxes, kill it. You will get a chicken egg for health. Note: If you do not kill the snake it will bite you and take health away.
You can kill the merchant at any time in the game. On the normal difficulty setting, he just dies then comes back at the next place, or sometimes when you leave the room and come back in. However, on the professional difficulty setting, once he dies, he remains dead.
At the beginning of the game, if you leave a hen alone in Pueblo they should lay at least one golden egg (which fully restores health when used). Go to the weapon/health screen and select the egg. It should allow you to equip the egg. At the screen, Leon will throw the egg up and down, looking smug. Additionally, the golden egg is the best healing item, as it fully heals you and only takes one space in your case.
Collect some eggs, equip them, and throw them at Ashley. They will not harm her and it is funny. Aim from a distance to get used to them. They are lighter than a grenade and fly far when thrown. Note: She will duck when in close proximity.
When Ashley is on a cliff or still up a ladder, you can aim your gun up at her. She will grab her skirt and call you a pervert.
Normally, if you jump down a ladder and try to look up Ashley's skirt, she will grab it and call you a pervert. However, there is a location where she does not do this. In Chapter 2-3, go to the lifts, after going down one of the paths. Climb onto one and go all the way down to the other side, shooting the Gonadas coming up on other lifts and the ones on the platforms. Once you get all the way down, go down the stairs nearby. Go to the cave that is here that has window-like holes. Be careful, as there are two dynamite wielding Gonadas at the entrance. Kill them then jump over the wall and go up the ladder. Kill the Gonada. Jump down, but leave Ashely up there. Try looking up her skirt with a sniper. She will not grab her skirt and call you a pervert because she is too high up. Note: There are more ladders where you can do this. Find one with a large drop and it should work. For example, if you have already gotten past Chapter 2-3, you can do this trick on the ladder you go down just after defeat Saddler in the final chapter.
After you defeat Ramon Salazar, walk further and there will be an intermission sequence where Ada will ask Leon if he needs a ride, and he accepts. When Ada brings him to the island, she will hook a rope onto the top of a cliff and say" I have some business to take care of". While she is saying that, look at her skirt (especially when she goes to jump up). You can also see more of Ashley than usual when you jump out the window of the church and when you get on the jet ski.
Look behind every painting of Saddler to find 5,000 Pesetas.
When you are in the area where you are just about see the intermission sequence with Luis dying, there will be a door that lets you know that you will need another person for it. After you get Ashley back, return to this door. Give Ashley a piggyback and she will open the door. Inside will be a lot of treasure, and the powerful Broken Butterfly. You do not have to buy it from the merchant or sell it for money. Additionally, the strongest Magnum is not the Killer 7. When you tune up and buy the exclusive option of the Broken Butterfly its power will increase to 50.0, far stronger than the Killer 7's 35.0. You can kill a Boss in four shots.
In Chapter 1-3 in the church, turn right. Go to the small path at the back of the church. You will see a blinking object. Get near it, then press X to check. After that, first rotate seven times using option 3, another five times using option 4, then one more time with option 3. You will hear a sound and can now get the Green Catseye.
When you first get to the church, defeat everyone in the area. Then, return to the church and shoot the bell above. Villagers will arrive in a groups of three to six Gonados. You can continue this process as much as desired.
You can kill the fish and use them as recovery items in the sewer area shortly after the beginning of Chapter 1-2. It is a little after the place where you face the two enemies who throw dynamite at you.
Before the end of the chapter, there is a puzzle in the church. The puzzle is a simple mix of colors. Three different designs surround the main design. The colors are red, green, and blue. When you enter the church, turn to the left and go down the little hall. Climb the ladder. When you are up there, you will see that the way to the door is barred. You must get to the other side of the church by jumping on and off of the chandelier. On the other side, there is a set of switches. When you activate it, the puzzle starts. The goal is to turn the designs so when combined, they are the same as the middle design. Turn red twice, green three times, and blue once. When combined, it should create the design. Then, go in and grab Ashley.
The quickest way to complete the puzzle when playing as Ashley in Chapter 3-4 is as follows. The layout of the puzzle's squares is referred as:
- 1 2 3
- 4 5 6
- 7 8 9
- 4 5 6
Press X on the following in this order: 4, 7, 8, 9, 6, 3, 1, 7, 9.
Note: Save your game before each encounter when trying to see the following death scenes:
Betrayal: When you are in the cabin surrounded by Ganados, shoot Luis Sera about five to eight times. An intermission sequence will begin.
Chief Mendez: In the barn fight, do not evade his grab in the intermission sequence.
Del Lago (before fighting him): Stand on the dock by the lake where you fight the giant alligator (Del Lago). Fire your shotgun into the water several times. Eventually, Del Lago will come out and eat you.
Del Lago (when fighting him): After getting knocked out of the boat, swim back until you are just in reach of the boat. Del Lago will appear from underneath. Additionally, after killing Del Lago, do not cut the rope.
Giant insects: Let them vomit on you.
"It": "It" has three ways of killing Leon. The first is when he is on the roof. He will grab Leon and snap his neck. Another is when he has the scissors tail. He will grab Leon by the legs and cut him in half. The finwl way happens after the three cages fall and the final fight on the cliff side begins. Shoot him until he goes underground. Allow him to kill you when he pops from under you.
Knife fight: At the end, let him press the knife through the cavity.
Molotov cocktails: In the beginning of the game, go up the ladder into the tower and wait for the villagers to burn you alive.
Prison Boss: Have low life and let him kill you with the first hit of his charge. He should impale you twice.
Regenerators: Both normal and spiked varieties have their own style of killing Leon.
Two Los Gigantes: In the magma floor/pool, activate the switch and stand next to the pool.
Trap door floor: Let Leon fall through the trap door that Salazar actives.
Wolves: When they jump on you, they will ravage your face. Once Leon is killed, look at their teeth.
Wear Leon's gangster costume and have the Chicago Typewriter as a weapon. Hold R1 and press Square. Leon will take off his hat, re-adjust it, then put it back in place. Repeat this until he throws his hat in the air, catches it, then strikes a pose.
When using Ashley's knight costume and Leon's gangster costume, watch Leon as he tries to catch Ashley whenever you need her to come down from a raised platform or ladder. He will fall on the ground with one knee, and as he comes up from the ground, he will grab his back in pain.
After you unlock Leon's special costume, complete Chapter 1-3. In the intermission sequence after the game prompts you to save, Leon will have a strange dream that the egg hatched and is taking over his body. One part shows it taking over his arm, but the secondary costume prevents Leon from looking at his skin. Leon still acts as though he can see it, and the intermission sequence plays through normally after that.
In the Mercenaries mini-game, play as John Krauser or Hunk. Notice that both of the character's theme songs are from P.N. 03 levels.
Listen closely when you kill the villagers. Some of them will say "Lord Saddler" as they reach out just before they die. Note: This may only happen after completion of the game.
Try not to get surrounded by them. Make sure they are in a group. Take out whatever rifle you have and shoot them all in the head until the snake thing appears. Wait until they are all like, then throw a flash grenade to kill all of them at once. This works well on all of them, and saves ammunition.
When you enter the town, kill everyone. When the second wave of people arrives, also kill all of them. You can then go into the house and they will not come out. Additionally, during the mine cart section of Chapter 4-2, the mine car will stop and lots of enemies and two chainsaw men will load into the stopped cars. To avoid most of this encounter, be in the front car and immediately shoot the switch. The cars will start moving, and you will have only have about four enemies to kill.
When you meet a man with the chainsaw, shoot him with the shotgun and incendiary grenades. You can also use your handgun, but you will probably get killed. Note: The shotgun is found in the building that is diagonal from the tower.
When you start, Del Lago is towing you and heading toward the pieces of land in the middle. Steer to avoid them and harpoon him as soon as you can afterwards (before it lets go). Next, aim a harpoon and throw it at any sign of movement so that you will not be knocked off the boat. After awhile it will go away, then charge at the boat. Throw as many harpoons at it as possible before it reaches the boat. If you get knocked out, press X until you get back in. Repeat this process until the intermission sequence starts and Del Lago retreats.
The zombie dogs are brown colored. You will find one in the beginning. The zombie dogs will not attack you until you meet Chief Mendez. The dogs will have parasites sticking out of them after chapter 3. A shotgun will kill them easily. Note: Do not kill the white dog in the trap. It will help you fight the Gigante.
Either weapon works; feel free to experiment. When the battle starts, check out the shacks and get all of the items that you can. When he gets close, run between his legs, get behind him, then open fire. When he is approaching you, use the shotgun and keep shooting him in the head while avoiding his attacks. When he roars and starts moving around, something will pop out of his back. Before it kneels on the ground, get in close until the action command that reads "Climb" appears. Use it to get on his back. The screen will indicate which button to use to slash. Press that button as fast as possible until you get off. Repeat the process one to three more times to defeat him. Additionally, when facing the El Gigante, buy a rocket launcher; it will kill him in one hit instead of wasting your other ammunition.
You will have to fight four El Gigantes (the big monster that breaks through the door and picks up and crushes Leon). You will fight one by yourself, one with the girl, and two at the same time by yourself. The quickest way to kill them is to buy a rocket launcher immediately before the fight so that you do not take waste space in you inventory. Throw a flash grenade to stun him, then run around behind and shoot him in the back. You will kill him in one hit. The same can also be done on most of the Bosses. If this does not kill them, it will do a lot of damage.
To win easily against the two El Gigantes in Chapter 4-2, go up the ladder and go down the rope on the other side of the room to activate the mechanism. It will open the circle in the middle of the room and take an El Gigante into the lava. Do not try it a second time; the mechanism will not work again. Just use the rocket launcher to finish the remaining El Gigante.
After you survive the raid, you must choose a path to open; left or right. Open the right gate and it will take you to El Gigante. Use the shotgun and make the boulder drop down on his head when he arrives. Then, turn around and kick the door six times to knock the chains off it. If you are still standing outside the door when you see Gigante approach you from behind, do not panic; just get out of there quickly. He does not attack for a few seconds after he comes up behind you. The knife or a gunshot may help destroy the chains quicker, but kicking works. Go through another door in the same fashion and somewhere along the way you should find a key. It may be in one of the last huts you see toward the center. If you are quick enough, you can escape El Gigante and make it through the door alive with Ashley.
If you are on a bridge and there are open areas, take out a weak gun. One shot will make them fall off the bridge. However, you will not get any items from them.
You do not need a special scope to kill them. Buy the Killer 7 Magnum and use it on them. After three or four shots, they will go down. Shoot it in the sheet until there is a hole. Then, shoot its head. After that, the body will explode then the legs will fall over and leave 5,000 gold. Additionally, another way to kill the Regenerator creatures is to shoot their head or chest with the shotgun. Then, blast a leg away; it will fall on the ground. Then, take out an incinerator grenade (the red ones) and throw it at them. If done correctly, he will burn on the ground and die.
If you are able to hit the flying insect enemies in the cave area while they are airborne, they will die in just one hit. Any weapon works, though the shotgun is recommended. This will help conserve your ammunition. If they manage to land, you will use about three to four shogun rounds from a Stock Striker (firepower 6.0).
When you are in the castle and you fire at the Gothic Illuminados, it is best to fire at their knees. They will fall on them and allow you to use a suplex move instead of a kick. You will then throw them over your head and smash their head in the ground. Note: In mercenary mode, the same goes for the rest of the mercenaries.
If you are low on ammunition, try to avoid these enemies. The zombies have orange eyes. When killed, the parasite in them will come out of their heads. Stay away from it and shoot it from a distance. If you are too close, the parasite will cut your head off.
In the area where Ashley is carried away by the flying insects, you can destroy the nest that is hanging from the ceiling. After it is destroyed, you will find a lot of green and red eyes, and if you are lucky, even a blue one. This is a good way to get the Butterfly Lamp filled with all three jewels early so that you can get some extra money for upgrades.
Krauser is the mean-looking Russian commando with the red beret. The first encounter is nothing more than action commands. The second encounter, you can kill him. For this battle, the weaponry you need is the semi-auto rifle and the Broken Butterfly. These two should be maxed out, with exclusives and everything else. If you are short on resources, worry more about getting the Broken Butterfly's exclusive, as it really increases the firepower. In the room where the long and hardest fight takes place, just run to the edge, taking the contents of a barrel along the way. Jump down the edge. Run across the corridor-like area until an intermission sequence starts, Krauser will tell you where Ashley is (not really) and say that you need three insignia to open the gate. He will say that one is in the north and in the east, and that he has the last one. Then, he will show his TMP. After that, the battle starts. Use the rifle to peg him in the head, but be quick. When he shows himself, he does not leave a big window of time to hit him. After about one or two shots he will engage close quarters. The best thing to do is take out the magnum and hit him anywhere. One shot and he will throw a flash grenade. From there, continue. There is a building at the end of the first fight with Krauser in this battle. Ignore the ladder. It is a waste of your time. Open the door and proceed. Turn the corner to find Krauser again. Keep the magnum out. He will be on a building, sniping you. Run toward the building. Use some caution when he starts with the mine arrows. When you are close enough to the building he will jump down and begin close quartering again. Hit him with the magnum. If you do not hit him the first time he may get close enough to use his knife. Either back up to avoid the hit, or (if becomes surreal and he tries to hit you multiple times), enter the action commands as they appear to avoid a slash or a deadly stab to the heart. After he throws another flash grenade, go to the right of the building and walk along the side. It is a path to the next fight with Krauser. This is also where you get the first insignia. In this fight, Krauser will switch between sniping and close quartering. While he is sniping, get under the roof he stands on and enter the action icons to avoid the grenades. When he gets down, aim and shoot. It will be a little tricky because the laser does not show up on Krauser, and you may need to wait until he says, "Come on! Come out and fight like a man!" The important thing is to shoot him. After he throws another flash grenade, a statue will rise. Push it to the square on the other side of the broken wall. This will open up two switches to be used; one to get out of the area you are in and the other to carry on to the last fight. Flip the first switch and go back down the path. When you get to the building, go around the backside of it and go straight to the second switch. Be careful. Krauser will be waiting for you around the corner, heading toward the switch. This starts the second to last shuffle. Just shoot him with the magnum. Open the door and jump down. You see that there are bombs around. Shoot them at a safe distance. Proceed through this trench to the end, shooting any bombs or flying turrets you encounter. Near the end of the path, Krauser will say something and you will have the choice of responding. In the tower at the end, climb the ladder. At the top you can go to the other tower and pick up some ammo and an herb if desired; or collect the second insignia and start the last fight. Krauser does not use his weapon anymore. However, his left arm turns into a group of blades. The fight will commence with an action command. You will dodge if you hit it correctly. You will hang on the edge if you do not. If this happens, press X to get up. The weapon you use is your choice. The magnum is recommended, as you only have three minutes to kill him and get out of the room. This is where timing and aim counts the most. The shooting order is as follows: feet, head. You can use the rifle to get him down, but for the head shot, it is better to use the magnum. If done correctly, you should kill him in a little over a half a minute. After he is dead, go down the ladder, and through the newly opened gate. Jump down, put in the insignia, and leave.
To easily defeat Krauser's final form, when his arm is mutated just use your knife whenever his guard is down. It is possible to defeat him in a little over a minute under the pro difficulty setting by using this technique. Additionally, when fighting Krauser, instead of wasting ammunition, use your knife. You should only have to hit him four or five times before he dies.
Instead of firing at Los Illuminados when there parasite is exposed, use a flash grenade to destroy the parasite instead of using your weapon.
When inside the castle, an obstacle blocks your path (two fire breathing statues) To shut it off, you must enter the prison (the key is on a painting near the obstacle). When you go into the prison, equip either the TMP or shotgun and tell Ashley to wait atop the stairs. After the intermission sequence showing what the boss looks like, kick down the cell door and get close to the switch to initiate the battle. If you go up the stairs to try to escape, the door will shut. Try walking as much as possible, as he is sensitive to sound. You can use the bells at each end of the prison by shooting at them, but they can only be used once. Stay close to walls so that he gets stuck when he tries to attack you. Do your best to avoid his attacks, as they take much damage and there is only one Green Herb in the area. His only weakness is the spider thing on his back. When he is stuck in a wall, concentrate all of your firepower on the the weak point until he recuperates. After awhile, he will let his guard down and walk around. This is when he is most vulnerable, besides when he is stuck in a wall. Repeat this as many times as needed to kill him. When you put Ashley atop the steps, she is out of harm's way. Additionally, make sure that he is closer to the bell than he is to you. Shoot it with your handgun. If he is closer to you, he hears the gunshot. Then, switch to the rifle and aim just in front of the bell. If you aimed well and timed your shot correctly, you can shoot him in the back before he destroys the bell.
Look at his legs. If you see an eyeball, shoot it until you can see the eyeball in his mouth. Get near it and press Action. Do this about three times, then go across the bridge and get the rocket launcher. Shoot it at him. Then, go down, get Ashley, and ride the jet ski.
The most effective way to win this battle is to have the Mine Thrower and some grenades. Start the battle by running past Saddler to the end platform and climb up the ladder. Wait for Saddler to get close to where you are and throw the switch. This will trigger steel beams to crash into him. Saddler will flop down on the ground. Quickly jump off the platform and go near him. Press X to trigger Leon to "climb up". Leon will stab his eye. You must stab Saddler around six times to defeat him. Quickly run across the bridge and get ready to do an action command to jump when the bridge falls. As Leon grabs on, repeatedly tap X to climb up. Be aware if Saddler has not jumped over to where you are, he will throw steel beams and you will have to do action commands to dodge them. Run to the end, and once again climb up the ladder. Get ready to throw the switch and cause Saddler to fall and stab him. There are now multiple ways to get him to flop down. A single grenade is enough, as well as a Dart Mine. You can use these to get him to fall. You get also take out the thermal scope for your sniper and target one of the four eyes on his legs. Those are all good ways to get Leon to stab his eye. Note: Stabbing Saddler's eye is the only way to damage him. Finally, when you haved stab him enough an intermission sequence will appear, and Ada will throw a Rocket Launcher (Special) to you to finish the job. Grab it across the bridge and make room for it in your case. Point and shoot at Saddler, and the final battle intermission sequence will begin.
Note: This trick requires the basic sniper rifle fully upgraded with the Exclusive Upgrade. Make a note of the dodge actions at various times during this battle. Start off by running to the side of the platform on the top. Quickly shoot the tentacle in front of you, making sure that you dodge if needed. With the upgraded sniper rifle, it will only take one shot for the tentacle to retract. Ignore Salazar's eye and other tentacles. Only focus on the tentacle closest to you. After some point, Salazar himself will emerge from the upper back of the monster. Use your sniper to pick him off. After you get about two shots in, he will go back into hiding. By now that tentacle should have returned. Shoot it once to take care of it for awhile. Repeat the process of shooting Salazar and the tentacle, and the battle will cause Leon to take little damage. If you run out of ammunition for the sniper rifle, either drop down and look for more in the barrels (but be prepared to fight the spider-like parasites or run pass them), or use your Punisher to snipe Salazar and just dodge the tentacle.
When you are in the castle, you may find a rocket launcher in the room where you must make a bridge to get to the other side. Take the rocket launcher but do not use it. Wait for your fight with Salazar to use it to end Chapter 4 easily. Immediately before the Boss battle with Salazar, take the TMP, the rocket launcher, some herbs, and a shotgun (Striker recommended, but the Riot Gun works). When you enter the room, watch Salazar fuse with the monster, then get to work. Use the shotgun or TMP on the tentacle to your left until it goes away. Grab the item that is at the end, then fire with the TMP until Salazar appears. Then, equip that rocket launcher and fire for a one hit kill. Get the 30,000 or 50,000 Peseta that he drops. This will pay for the rocket you used, and you will save health for the next chapter. Once the Pesata is collected, go down into the pit and pick up the remaining items. You can then leave and proceed to Chapter 5.