Accomplish the indicated achievement to get the corresponding number of Gamerscore points:

Sprint 2 Minute Drill (30 points): Win after being behind in the final 2 minutes of a game. 5 min qtrs, All Pro (no co-op).
All Day No Way (40 points): Record 3 tackles for a loss on Adrian Peterson. 5 min qtrs, All Pro (no Pro Bowl, no co-op).
Buzzkill (40 points): Intercept a pass intended for Randy Moss. 5 min qtrs, All Pro (no Pro Bowl, no co-op).
Fight for the Fumble (30 points): Win possession of the ball after a fumble pile-up. 5 min qtrs, All Pro (no co-op).
From Me To You (40 points): Complete a pass for a TD with your partner in an Online Co-op game. 5 min qtrs, All Pro.
Frozen Tundra (30 points): Win at Lambeau Field in freezing weather. 5 min qtrs, All Pro (no co-op).
The Gang's All Here (50 points): Trigger a gang tackle with 7+ players. 5 min qtrs, All Pro (no co-op) .
Go Back to Basketball (40 points): Tackle Antonio Gates inside the 5 yard line. 5 min qtrs, All Pro (no Pro Bowl, no co-op).
Go Bag Some Groceries (40 points): Force Kurt Warner to fumble on a sack. 5 min qtrs, All Pro (no Pro Bowl, no co-op).
Have to Be This Tall to Ride (40 points): Stiff arm or juke Bob Sanders. 5 min qtrs, All Pro (no Pro Bowl, no co-op).
Hey Buddy! (50 points): Complete a lateral with your partner in an Online Co-Op game. 5 min qtrs, All Pro.
Larry Stickyfingers (40 points): Get 10 user catches (no drops) with Larry Fitzgerald. 5 min qtrs, All Pro (no Pro Bowl, no co-op).
Laser Arm? (40 points): Intercept Peyton Manning 3 times. 5 min qtrs, All Pro (no Pro Bowl, no co-op).
Look what I found! (80 points): Win a fumble pile-up in the end zone for a TD. 5 min qtrs, All Pro (no co-op).
Mr. Not-So-Perfect (40 points): Intercept a Tom Brady pass. 5 min qtrs, All Pro (no Pro Bowl, no co-op).
Nano (50 points): Sack the QB before he can hand the ball off. 5 min qtrs, All Pro (no co-op).
Nothing Without the Dark Visor (40 points): Force a LaDanian Tomlinson fumble. 5 min qtrs, All Pro (no Pro Bowl, no co-op).
Pocket Monster (80 points): Stay in the pocket for at least 10 seconds. 5 min qtrs, All Pro (no co-op).
Super Bowl MVP-like (50 points): Catch a TD to take the lead with under 30 seconds left. 5 min qtrs, All Pro (no co-op).
Why Can’t We Be Friends? (75 points): Complete an online Co-Op game. 5 min qtrs, All Pro.
Wounded Duck (50 points): Complete a pass to an unintended receiver. 5 min qtrs, All Pro (no co-op).

Additionally, there are three secret achievements:

Mature Newbie (10 points): Create a player or Superstar at the oldest possible age.
Safety Inspection Required (10 points): Create a team from Springfield.
Well played. Really. (5 points): Throw the ball away on 4th down. 5 min qtrs, All Pro (no co-op).

The following achievements require the "AFL Legacy Pack" bonus downloadable content:

Blast From The Past (30 points): Win an AFL-themed Madden Moment with AFL presentation turned ON.
Orange Sherbet Anyone? (30 points): Win an exhibition game with AFL presentation turned ON. 5 min qtrs, All Pro (no co-op).
AFL Invades Franchise Mode (30 points): Win an offline franchise AFL Legacy game with AFL presentation turned ON.
AFL Goes Online (30 points): Play online wearing AFL jerseys. 5 min qtrs, All Pro (no co-op).

Additionally, there is one secret achievement with the "AFL Legacy Pack" bonus downloadable content:

Secret Achievement (30 points): Unknown.